British scientists have discovered why people die from a “broken heart”, that is takotsubo cardiomyopathy.
Source: Jutarnji List
Takotsubo cardiomyopathy can occur when a person under long-term stress is struck by a traumatic event such as the death of a loved one, learning a certain life-threatening illness, losing a large sum of money, or ending a history of ‘love.
“Broken heart syndrome” can be the cause of a number of health problems such as heart failure, extremely low blood pressure, the formation of blood clots on top of the left ventricle, arrhythmias and rupture (crack) of the wall of the heart.
In Dr. In 1990, Hikaru Sato and colleagues in Japan diagnosed the patient with taktsubo cardiomyopathy for the first time after severe emotional stress. The disease got its name because the changes in the patient’s left ventricle resembled an octopus fishing vessel used in Japan.
In the United States and Europe, such cardiomyopathy was recognized only in the late 90s of last century. The International Register for Takotsubo was created at the University Hospital of Zurich, in which 1,750 patients with Takotsubo cardiomyopathy were registered from 25 cardiovascular centers in 9 countries in the period from 1998 to 2014.
It is significantly more common in women (90% of all patients), especially in menopause after the age of 50 years.
New research, funded by the British Heart Foundation and published in a journal “Cardiovascular research”, Showed that two molecules associated with increased stress levels play a key role in the onset of “broken heart” syndrome.
Experts at Imperial College London have found that increased levels of microRNA molecules 16 and 26a, which are responsible for RNA suppression and post-transcriptional regulation of gene expression, increase the likelihood of developing such cardiomyopathy.
A combination of prolonged stress and dramatic shock
During the study, researchers studied how heart cells in humans and mice respond to adrenaline after exposure to these molecules.
When the scientists studied the heart cells that were treated with the mentioned microRNA molecules, they noticed that those cells are more sensitive to adrenaline and that it is possible that they lose the power of contraction. The changes associated with “broken heart” syndrome were then observed at lower levels of adrenaline.
MicroRNA molecules 16 and 26a have been linked to depression, anxiety and increased stress levels, meaning that a combination of prolonged stress and dramatic shock can cause symptoms that are linked to “broken heart” syndrome.
Experts hope that blood tests or drugs that may react to such conditions will now be developed.
“Takotsubo cardiomyopathy is a serious disease, but so far we don’t know why it occurs. We don’t understand why some people react to a sudden emotional shock and others don’t,” said Sian Harding, professor of cardiovascular pharmacology at Imperial College. London.
“This research will help us better understand this mysterious disease, and it could also help us more easily identify those threatened by takotsubo. Further research is needed to determine whether drugs can prevent and prevent these microRNA molecules.” Breaking the heart ’,” said Professor Metin Avkiran.