Scientists are developing more advanced treatments in the treatment of covids – the goal is to take it as a pill.




A team of researchers from the University of Alberta has discovered new antiviral drugs that could lead to a safer and more effective treatment than covid 19 than other current drugs in development.


Source: 555vq

Photo: Profimedia

Photo: Profimedia

In a recent paper in the Journal of Medicinal Chemistry, researchers have identified new protease inhibiting compounds that interfere with the ability of the SARS-CoV-2 virus to replicate, and also strongly inhibit other non-SARS coronaviruses.

In another paper in RSC medical chemistry, they also identified inhibitors that work through a different mechanism, reports Technology.

The researchers reported that the two series of compounds demonstrated good selectivity, indicating a relationship between efficacy and side effects for potential therapeutic treatment.

“We have made more than 50 compounds and reviewed them for efficacy both in vitro with recombinant protein and in live virus cell studies, and these compounds show a very high protease specificity,” said Doanin Lemieuk, principal investigator. professor of biochemistry in Medical -. Faculty of Dentistry and Director of the Membrane Protein Disease Research Group.

His lab received funding from the Canadian Institute for Health Research and Alberta Innovates, and said the next step for the new compounds would be to test the pharmacokinetics of honey, measure how drugs are absorbed, distributed, metabolized and excreted. .

It will also test compounds for SARS-CoV-2 virus variants that appear to be more contagious and virulent.

The goal is to develop a treatment that could be taken as a pill, not as an intravenous drug that can only be used in a hospital.

Teams are also continuing to test an improved version of the drug that was initially developed to treat coronavirus-induced diseases in cats, which they hope will be more effective at lower doses.

The team’s first paper on drugs, published in Nature Communications, has been accessed more than 58,000 times and cited more than 130 times, making it one of the most accessible documents on covid 19 by 2020.

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